Publications – pHion Therapeutics

SCIENTIFIC PUBLICATIONS

pHion Therapeutics provide an environment and culture of scientific excellence and innovation.

PUBLICATION SPOTLIGHT

6 July 2017

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

Adv Healthc Mater. 2017 Jul; 6(13). doi: 10.1002/adhm.201601412. Epub 2017 Apr 24. PMID: 28436620.

Udhayakumar VK, De Beuckelaer A, McCaffrey J, McCrudden CM, Kirschman JL, Vanover D, Van Hoecke L, Roose K, Deswarte K, De Geest BG, Lienenklaus S, Santangelo PJ, Grooten J, McCarthy HO, De Koker S.

15 September 2014

Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery

J Control Release. 2014 Sep 10;189:141-9. doi: 10.1016/j.jconrel.2014.06.048. Epub 2014 Jul 1. PMID: 24995949.

McCarthy HO, McCaffrey J, McCrudden CM, Zholobenko A, Ali AA, McBride JW, Massey AS, Pentlavalli S, Chen KH, Cole G, Loughran SP, Dunne NJ, Donnelly RF, Kett VL, Robson T.

PUBLICATIONS LISTING

Gene Therapy

6 June 2022

Development of a Spray-Dried Formulation of Peptide-DNA Nanoparticles into a Dry Powder for Pulmonary Delivery Using Factorial Design.

Pharm Res. 2022 Jun;39(6):1215-1232.

Munir M, Kett VL, Dunne NJ, McCarthy HO

10 February 2021

Rational design and characterisation of a linear cell penetrating peptide for non-viral gene delivery.

J Control Release. 2021 Feb 10;330:1288-1299

McErlean EM, Ziminska M, McCrudden CM, McBride JW, Loughran SP, Cole G, Mulholland EJ, Kett V, Buckley NE, Robson T, Dunne NJ, McCarthy HO.

1 June 2018

Gene therapy with RALA/iNOS composite nanoparticles significantly enhances survival in a model of metastatic prostate cancer

Cancer Nanotechnol. 2018;9(1):5

McCrudden CM, McBride JW, McCaffrey J, McErlean EM, Dunne NJ, Kett VL, Coulter JA, Robson T, McCarthy HO.

31 December 2016

Systemic RALA/iNOS Nanoparticles: A Potent Gene Therapy for Metastatic Breast Cancer Coupled as a Biomarker of Treatment.

Mol Ther Nucleic Acids. 2017 Mar 17;6:249-258.

McCrudden CM, McBride JW, McCaffrey J, Ali AA, Dunne NJ, Kett VL, Coulter JA, Robson T, McCarthy HO.

16 September 2016

Non-viral gene delivery utilizing RALA modulates sFlt-1 secretion, important for preeclampsia

Nanomedicine (Lond). 2021 Sep;16(22):1999-2012.

McNally R, Alqudah A, McErlean EM, Rennie C, Morshed N, Short A, McGrath K, Shimoni O, Robson T, McCarthy HO, McClements L

13 February 2016

Transcending epithelial and intracellular biological barriers; a prototype DNA delivery device

J Control Release. 2016 Mar 28;226:238-47

McCaffrey J, McCrudden CM, Ali AA, Massey AS, McBride JW, McCrudden MT, Vicente-Perez EM, Coulter JA, Robson T, Donnelly RF, McCarthy HO.

24 November 2015

Development of polymeric-cationic peptide composite nanoparticles, a nanoparticle-in-nanoparticle system for controlled gene delivery

Int J Nanomedicine. 2015 Nov 24;10:7183-96

Jain AK, Massey A, Yusuf H, McDonald DM, McCarthy HO, Kett VL.

30 September 2015

RALA-mediated delivery of FKBPL nucleic acid therapeutics

Nanomedicine (Lond). 2015 Oct;10(19):2989-3001.

Bennett R, Yakkundi A, McKeen HD, McClements L, McKeogh TJ, McCrudden CM, Arthur K, Robson T, McCarthy HO.

1 July 2014

Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery

J Control Release. 2014 Sep 10;189:141-9

McCarthy HO, McCaffrey J, McCrudden CM, Zholobenko A, Ali AA, McBride JW, Massey AS, Pentlavalli S, Chen KH, Cole G, Loughran SP, Dunne NJ, Donnelly RF, Kett VL, Robson T.

Immuno-oncology

9 July 2019

DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen

Acta Biomater. 2019 Sep 15;96:480-490.

Cole G, Ali AA, McErlean E, Mulholland EJ, Short A, McCrudden CM, McCaffrey J, Robson T, Kett VL, Coulter JA, Dunne NJ, Donnelly RF, McCarthy HO

1 June 2018

DNA vaccination for cervical cancer: Strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system

Eur J Pharm Biopharm. 2018 Jun;127:288-297

Cole G, Ali AA, McCrudden CM, McBride JW, McCaffrey J, Robson T, Kett VL, Dunne NJ, Donnelly RF, McCarthy HO.

6 July 2017

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

Adv Healthc Mater. 2017 Jul; 6(13). doi: 10.1002/adhm.201601412. Epub 2017 Apr 24. PMID: 28436620.

Udhayakumar VK, De Beuckelaer A, McCaffrey J, McCrudden CM, Kirschman JL, Vanover D, Van Hoecke L, Roose K, Deswarte K, De Geest BG, Lienenklaus S, Santangelo PJ, Grooten J, McCarthy HO, De Koker S.

13 April 2017

DNA vaccination for cervical cancer; a novel technology platform of RALA mediated gene delivery via polymeric microneedles

Nanomedicine. 2017 Apr;13(3):921-932

Ali AA, McCrudden CM, McCaffrey J, McBride JW, Cole G, Dunne NJ, Robson T, Kissenpfennig A, Donnelly RF, McCarthy HO

2 January 2017

Dissolving microneedles for DNA vaccination: improving functionality via polymer characterisation and RALA complexation.

Hum Vaccin Immunother. 2017 Jan 2;13(1):50-62.

Cole G, McCaffrey J, Ali AA, McBride JW, McCrudden CM, Vincente-Perez EM, Donnelly RF, McCarthy HO.

Regenerative Applications

3 November 2022

Delivery of a peptide/microRNA blend via electrospun antimicrobial nanofibres for wound repair

Acta Biomater. 2023 Jan 1;155:304-322

Bombin ADJ, Dunne N, McCarthy HO.

17 November 2021

Peptide/MicroRNA-31 nanomedicine within an electrospun biomaterial designed to regenerate wounds in vivo

Acta Biomater. 2022 Jan 15;138:285-300.

Ej M, Em M, N D, Ho M. A

30 September 2020

Collagen/GAG scaffolds activated by RALA-siMMP-9 complexes with potential for improved diabetic foot ulcer healing

Mater Sci Eng C Mater Biol Appl. 2020 Sep;114:111022 Epub 2020 Apr 30. PMID: 32993972.

Yan LP, Castaño IM, Sridharan R, Kelly D, Lemoine M, Cavanagh BL, Dunne NJ, McCarthy HO, O’Brien FJ.

2 June 2020

Synthesis and Evaluation of a Thermoresponsive Degradable Chitosan-Grafted PNIPAAm Hydrogel as a “Smart” Gene Delivery System

Materials (Basel). 2020 Jun 2;13(11):2530

30 October 2019

Delivery of RALA/siFKBPL nanoparticles via electrospun bilayer nanofibres: An innovative angiogenic therapy for wound repair

J Control Release. 2019 Dec 28;316:53-65

Mulholland EJ, Ali A, Robson T, Dunne NJ, McCarthy HO.

8 March 2019

Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues

J Control Release. 2019 May 10;301:13-27.

Gonzalez-Fernandez T, Rathan S, Hobbs C, Pitacco P, Freeman FE, Cunniffe GM, Dunne NJ, McCarthy HO, Nicolosi V, O’Brien FJ, Kelly DJ.

27 September 2017

Influence of alginate backbone on efficacy of thermo-responsive alginate-g-P(NIPAAm) hydrogel as a vehicle for sustained and controlled gene delivery

Mater Sci Eng C Mater Biol Appl. 2019 Feb 1;95:409-421

Chalanqui MJ, Pentlavalli S, McCrudden C, Chambers P, Ziminska M, Dunne N, McCarthy HO.

29 March 2017

Mesenchymal stem cell fate following non-viral gene transfection strongly depends on the choice of delivery vector

Acta Biomater. 2017 Jun;55:226-238.

Gonzalez-Fernandez T, Sathy BN, Hobbs C, Cunniffe GM, McCarthy HO, Dunne NJ, Nicolosi V, O’Brien FJ, Kelly DJ.

7 March 2017

RALA complexed α-TCP nanoparticle delivery to mesenchymal stem cells induces bone formation in tissue engineered constructs in vitro and in vivo

J Mater Chem B. 2017 Mar 7;5(9):1753-1764.

Sathy BN , Olvera D , Gonzalez-Fernandez T , Cunniffe GM , Pentlavalli S , Chambers P , Jeon O , Alsberg E , McCarthy HO , Dunne N , Haut Donahue TL , Kelly DJ .

Small Molecule

4 May 2021

Exploiting the anticancer effects of a nitrogen bisphosphonate nanomedicine for glioblastoma multiforme

J Nanobiotechnology. 2021 May 4;19(1):127. PMID: 33947409; PMCID: PMC8097796.

Jena LN, Bennie LA, McErlean EM, Pentlavalli S, Glass K, Burrows JF, Kett VL, Buckley NE, Coulter JA, Dunne NJ, McCarthy HO.

4 April 2016

Potentiating the Anticancer Properties of Bisphosphonates by Nanocomplexation with the Cationic Amphipathic Peptide, RALA

Mol Pharm. 2016 Apr 4;13(4):1217-28.

Massey AS, Pentlavalli S, Cunningham R, McCrudden CM, McErlean EM, Redpath P, Ali AA, Annett S, McBride JW, McCaffrey J, Robson T, Migaud ME, McCarthy HO.

TECHNOLOGY

TECHNOLOGY

BENEFITS OF RALA

BENEFITS OF RALA